⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206747 | 0.75 | CRBN (0.33) | — | |
| SCHEMBL22993691 | 0.72 | — | — | |
| SCHEMBL21325306 | 0.70 | — | — | |
| SCHEMBL20206914 | 0.66 | KDM4E (0.32) | — | |
| SCHEMBL22623762 | 0.64 | — | — | |
| SCHEMBL19586830 | 0.61 | MAP3K14 (0.33) | — | |
| SCHEMBL19585689 | 0.61 | MAP3K14 (0.33) | — | |
| SCHEMBL2956440 | 0.59 | MAP3K14 (0.44) | — | |
| SCHEMBL6377869 | 0.58 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL24315849 | 0.58 | CRBN (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174271-B2 | 6-membered uracil isosteres | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2021-11-16 | — | — | US | disclosed |
| US-20190270756-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2019-09-05 | — | — | US | disclosed |
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |