Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 17/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207351 | 0.91 | PTGS2 (0.48) | APLNRPTGS2TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL20180772 | 0.86 | APLNR (0.39) | APLNRTSHRNPSR1 | |
| SCHEMBL22537211 | 0.84 | APLNR (0.70) | APLNR | |
| SCHEMBL20188046 | 0.82 | APLNR (0.73) | APLNR | |
| SCHEMBL20187809 | 0.80 | APLNR (0.60) | APLNR | |
| SCHEMBL20207348 | 0.77 | APLNR (0.69) | APLNRSMN1; SMN2 | |
| SCHEMBL20207275 | 0.77 | APLNR (0.64) | APLNR | |
| SCHEMBL22537233 | 0.77 | APLNR (0.57) | APLNR | |
| SCHEMBL20207583 | 0.77 | APLNR (0.72) | APLNR | |
| SCHEMBL22537175 | 0.77 | APLNR (0.72) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |