Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 11/20 | 0.62 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207605 | 0.94 | APLNR (0.71) | APLNR | |
| SCHEMBL20189164 | 0.83 | APLNR (0.87) | APLNR | |
| SCHEMBL20207465 | 0.83 | APLNR (0.71) | APLNR | |
| SCHEMBL20207490 | 0.80 | APLNR (0.71) | APLNR | |
| SCHEMBL20168139 | 0.77 | APLNR (1.00) | APLNR | |
| SCHEMBL20189416 | 0.76 | APLNR (1.00) | APLNRKCNN4 | |
| SCHEMBL20207585 | 0.73 | APLNR (0.68) | APLNR | |
| SCHEMBL20207252 | 0.73 | APLNR (0.69) | APLNR | |
| SCHEMBL20207348 | 0.72 | APLNR (0.69) | APLNR | |
| SCHEMBL20188829 | 0.66 | APLNR (1.00) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |