Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.32 |
| ▸ | HTR3B | O95264 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR1D | P28221 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR1E | P28566 | 2/20 | 0.32 |
| ▸ | HTR1F | P30939 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014113 | 0.77 | PSEN1 (0.44) | HTR2AALDH1A1 | |
| SCHEMBL20201658 | 0.76 | AKR1B1 (0.46) | SLC6A4SLC6A2SLC6A3CYP1A2 | |
| SCHEMBL21325078 | 0.71 | CYP1A2 (0.40) | HTR1DALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL20376205 | 0.71 | HSP90AA1 (0.37) | CRHR1HTR1DHTR1BALDH1A1 | |
| SCHEMBL645965 | 0.69 | ALDH1A1 (0.38) | HTR7ALDH1A1CYP1A2 | |
| SCHEMBL15014087 | 0.69 | ADRA2A (0.46) | SLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL8446375 | 0.69 | TAAR1 (0.41) | HTR2AHTR2CALDH1A1CYP1A2 | |
| SCHEMBL22964348 | 0.68 | SIGMAR1 (0.43) | ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL25446390 | 0.68 | PSEN1 (0.34) | — | |
| SCHEMBL25446391 | 0.68 | PDE3B (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098208-A1 | NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |