SCHEMBL20208029

SCHEMBL20208029

CC(C)(C)OC(=O)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.89

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 6/20 0.89
DDB1 Q16531 4/20 0.89
STAT3 P40763 6/20 0.66
GRAMD1A Q96CP6 4/20 0.61
CA2 P00918 2/20 0.60
HDAC8 Q9BY41 1/20 0.59
HDAC3 O15379 2/20 0.57
HDAC1 Q13547 2/20 0.57
HDAC2 Q92769 2/20 0.57
NCOR2 Q9Y618 2/20 0.57
BRD4 O60885 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22511880 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL29990702 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL22511903 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL21760067 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL25123413 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL20188589 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL23884233 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL23884311 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL25123821 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2
SCHEMBL21106634 1.00 CRBN (0.89) CRBNDDB1STAT3GRAMD1ACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125362-A1 TARGETED PROTEIN DEGRADATION OF PARP14 FOR USE IN THERAPY ABBVIE BIOTECHNOLOGY LTD (BM) 2026-05-07 US disclosed
EP-4731309-A1 KRAS PROTEOLYSIS TARGETING CHIMERAS Paq Therapeutics Inc. (US) 2026-04-29 EP disclosed
US-12479840-B2 HMG-CoA reductase degradation inducing compound UPPTHERA INC. (KR) 2025-11-25 US disclosed
WO-2025216628-A1 PROTAC COMPOUNDS UNIVERSITEIT LEIDEN (NL) 2025-10-16 WO disclosed
US-12404285-B2 KRAS G12D proteolysis targeting chimeras PAQ Therapeutics Inc. (US) 2025-09-02 US disclosed
EP-4598905-A2 CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS University of Florida Research Foundation, Incorporated (US) 2025-08-13 EP disclosed
US-20250051364-A1 KRAS G12D Proteolysis Targeting Chimeras PAQ Therapeutics Inc. (US) 2025-02-13 US disclosed
WO-2024263586-A1 KRAS PROTEOLYSIS TARGETING CHIMERAS PAQ Therapeutics Inc. (US) 2024-12-26 WO disclosed
CN-113677668-B Bifunctional compounds and methods for androgen receptor targeted ubiquitination 蒙特利诺治疗公司 2024-09-27 CN disclosed
US-20240317711-A1 AURKA SELECTIVE DEGRADATION INDUCING COMPOUND UPPTHERA INC. (KR) 2024-09-26 US disclosed
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-11-25 US disclosed
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-10-14 US disclosed
WO-2021201577-A1 HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND UPPTHERA (KR) 2021-10-07 WO disclosed
US-20210061811-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-03-04 US disclosed
WO-2020200291-A1 COMPOUNDS AND METHODS OF TREATING CANCERS CULLGEN (SHANGHAI) , INC. (CN) 2020-10-08 WO disclosed
WO-2020160198-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2020-08-06 WO disclosed
WO-2020160198-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2020-08-06 WO disclosed
WO-2020038415-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2020-02-27 WO disclosed
US-20190263823-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2019-08-29 US disclosed
WO-2018098280-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2018-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190263823-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE MDM2, MAP2K2, TTK CRBN 663/4885DDB1 755/4885STAT3 896/4885
US-20250051364-A1 KRAS G12D Proteolysis Targeting Chimeras KRAS, NRAS, HRAS CRBN 51/4885DDB1 1063/4885STAT3 963/4885
US-12404285-B2 KRAS G12D proteolysis targeting chimeras KRAS, NRAS, HRAS CRBN 51/4885DDB1 1063/4885STAT3 963/4885
US-20210061811-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE MDM2, MAP2K2, TTK CRBN 663/4885DDB1 755/4885STAT3 896/4885
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, NTRK1, ERBB2 CRBN 194/4885DDB1 418/4885STAT3 4012/4885
US-20260125362-A1 TARGETED PROTEIN DEGRADATION OF PARP14 FOR USE IN THERAPY PARP14, PARP16, PARP11 CRBN 26/4885DDB1 114/4885STAT3 1788/4885
US-12479840-B2 HMG-CoA reductase degradation inducing compound HMGCR, HMGB2, LDLR CRBN 1616/4885DDB1 798/4885STAT3 4250/4885
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 CRBN 330/4885DDB1 480/4885STAT3 3381/4885
US-20240317711-A1 AURKA SELECTIVE DEGRADATION INDUCING COMPOUND STUB1, AURKA, XIAP CRBN 757/4885DDB1 377/4885STAT3 1225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.