Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 7/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16727170 | 0.82 | LMNA (0.47) | F2CTRCMAOALMNASLC6A2 | |
| SCHEMBL16406694 | 0.82 | LMNA (0.45) | MAOALMNASLC6A2HPGD | |
| SCHEMBL28414941 | 0.81 | TLR4 (0.42) | TLR4TLR2MAOAPARP15PARP10 | |
| SCHEMBL14227724 | 0.81 | TLR4 (0.42) | TLR4TLR2PARP15PARP10PARP2 | |
| SCHEMBL13746027 | 0.80 | TLR4 (0.39) | TLR4TLR2PARP15PARP10PARP2 | |
| SCHEMBL16247136 | 0.80 | TLR4 (0.50) | TLR4TLR2MAOAPARP15PARP10 | |
| SCHEMBL12361326 | 0.78 | ALDH1A1 (0.42) | MAOALMNAMAOBHPGD | |
| SCHEMBL27910449 | 0.77 | NR1H4 (0.47) | TLR4TLR2KAT6APARP15PARP10 | |
| SCHEMBL10068819 | 0.77 | ALDH1A1 (0.43) | TLR4TLR2F2KAT6APARP15 | |
| SCHEMBL2007212 | 0.77 | SRC (0.45) | TLR4TLR2PARP15PARP10PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098208-A1 | NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |