Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MTHFD2 | P13995 | 5/20 | 0.35 |
| ▸ | MTHFD1 | P11586 | 4/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30038086 | 0.86 | MTHFD2 (0.37) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL20208677 | 0.86 | MTHFD2 (0.37) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL20208622 | 0.84 | HSD17B10 (0.49) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL20209301 | 0.84 | ESR2 (0.42) | KDM4EHPGDHSD17B10ALDH1A1POLB | |
| SCHEMBL31535204 | 0.80 | MTHFD2 (0.37) | ESR2NR1H2MTHFD2MTHFD1P2RX3 | |
| SCHEMBL20209038 | 0.80 | MTHFD2 (0.46) | KDM4EHPGDHSD17B10ALDH1A1POLB | |
| SCHEMBL31535587 | 0.78 | MTHFD2 (0.37) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL31535502 | 0.77 | MTHFD1 (0.38) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL31535483 | 0.77 | ESR2 (0.44) | MEN1KMT2AESR2NR1H2MTHFD2 | |
| SCHEMBL20209037 | 0.75 | MTHFD2 (0.47) | ESR2MTHFD2MTHFD1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546463-B1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018097162-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | 第一三共株式会社 | 2018-05-31 | — | — | WO | disclosed |