Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MTHFD1 | P11586 | 4/20 | 0.47 |
| ▸ | MTHFD2 | P13995 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 6/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354096 | 0.85 | MTHFD2 (0.48) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL20208675 | 0.84 | KDM4E (0.36) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL20208889 | 0.84 | MTHFD1 (0.47) | MTHFD1MTHFD2ERN1FHIT | |
| SCHEMBL20208562 | 0.83 | KDM4E (0.55) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL30037861 | 0.79 | MTHFD2 (0.62) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL20208624 | 0.79 | MTHFD2 (0.62) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL31535516 | 0.78 | ERN1 (0.42) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL31535335 | 0.77 | ERN1 (0.53) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL31535216 | 0.76 | ERN1 (0.42) | HSD17B10KDM4EHPGDALDH1A1TSHR | |
| SCHEMBL20208671 | 0.76 | MTHFD2 (0.48) | HSD17B10KDM4EHPGDALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546463-B1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | DAIICHI SANKYO CO LTD (JP) | 2022-12-07 | — | — | EP | disclosed |
| EP-3546463-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | Daiichi Sankyo Co., Ltd. (JP) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018097162-A1 | SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON | 第一三共株式会社 | 2018-05-31 | — | — | WO | disclosed |