Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325982 | 0.96 | PRMT6 (0.68) | PRMT6SMN1; SMN2ALDH1A1TDP1SIGMAR1 | |
| SCHEMBL29809392 | 0.96 | PRMT6 (0.68) | PRMT6SMN1; SMN2ALDH1A1TDP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9023633 | 0.94 | PRMT6 (0.66) | PRMT6SMN1; SMN2ALDH1A1TDP1SIGMAR1 | |
| SCHEMBL20209847 | 0.94 | PRMT6 (0.66) | PRMT6SMN1; SMN2ALDH1A1TDP1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10665202 | 0.93 | PRMT6 (0.64) | PRMT6SMN1; SMN2ALDH1A1TDP1SIGMAR1 | |
| SCHEMBL11339852 | 0.84 | PRMT6 (0.78) | PRMT6SMN1; SMN2ALDH1A1TDP1HRH3 | |
| SCHEMBL11192726 | 0.84 | PRMT6 (0.78) | PRMT6SMN1; SMN2ALDH1A1TDP1HRH3 | |
| Hydrochloric Acid SCHEMBL9024937 | 0.82 | MC4R (0.66) | PRMT6ALDH1A1SIGMAR1HRH3NCF1 | |
| Hydrochloric Acid SCHEMBL9024294 | 0.82 | NCF1 (0.69) | PRMT6SMN1; SMN2ALDH1A1SIGMAR1HRH3 | |
| SCHEMBL20210246 | 0.81 | HRH3 (0.70) | PRMT6SMN1; SMN2ALDH1A1TDP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-12-09 | — | — | US | disclosed |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-09-14 | — | — | US | disclosed |
| CN-108884092-B | Pyrazolo heteroaryl derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2021-06-29 | — | — | CN | disclosed |
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
| EP-3546457-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-10-02 | — | — | EP | disclosed |
| CN-108884092-A | Pyrazolo-heteroaryl analog derivative, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-11-23 | — | — | CN | disclosed |
| WO-2018095426-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | PRMT6 4530/4885SMN1; SMN2 4200/4885ALDH1A1 1071/4885 |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | TLR7, TLR3, TLR4 | PRMT6 4530/4885SMN1; SMN2 4200/4885ALDH1A1 1071/4885 |
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | PRMT6 4530/4885SMN1; SMN2 4200/4885ALDH1A1 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.