Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31460754 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM1AEHMT2RCOR1USP30 | |
| SCHEMBL889079 | 0.94 | USP30 (0.53) | USP30PIK3CDPIK3CACCNKCCNA2 | |
| SCHEMBL31460656 | 0.89 | CCNK (0.49) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL28717093 | 0.89 | CCNK (0.49) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL29494812 | 0.89 | CCNK (0.49) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL29527460 | 0.89 | CCNK (0.49) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL22787807 | 0.89 | CCNK (0.49) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL23003081 | 0.86 | USP30 (0.55) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL23003082 | 0.86 | USP30 (0.55) | USP30PIK3CDCCNKCCNA2CDK2 | |
| SCHEMBL31460649 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM1AEHMT2RCOR1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528796-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| WO-2025076441-A1 | COMPOUNDS OF GCN2 MODULATORS | Alesta Therapeutics BV (NL) | 2025-04-10 | — | — | WO | disclosed |
| US-20220227740-A1 | Modulators of RAS GTPase | TOSK, INC. | 2022-07-21 | — | — | US | disclosed |
| US-10934275-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-03-02 | — | — | US | disclosed |
| WO-2020214537-A1 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-3548476-A1 | IRE1 SMALL MOLECULE INHIBITORS | Quentis Therapeutics, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20190276434-A1 | IRE1 Small Molecule Inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2019-09-12 | — | — | US | disclosed |
| WO-2018102751-A1 | IRE1 SMALL MOLECULE INHIBITORS | QUENTIS THERAPEUTICS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |
| WO-2018102751-A1 | IRE1 SMALL MOLECULE INHIBITORS | QUENTIS THERAPEUTICS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934275-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | ALDH1A1 3482/4885KDM1A 2007/4885EHMT2 3194/4885 |
| US-20220227740-A1 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | ALDH1A1 4302/4885KDM1A 4435/4885EHMT2 3083/4885 |
| US-20190276434-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | ALDH1A1 3482/4885KDM1A 2007/4885EHMT2 3194/4885 |
| US-12528796-B2 | Modulators of RAS GTPase | KRAS, NRAS, HRAS | ALDH1A1 4254/4885KDM1A 4553/4885EHMT2 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.