Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13875069 | 0.80 | PNMT (0.54) | PNMTADRA2AASIC3HTR2AHTR2C | |
| SCHEMBL26601382 | 0.80 | PNMT (0.54) | PNMTADRA2AASIC3HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL4169138 | 0.79 | PNMT (0.53) | PNMTADRA2AASIC3HTR2AHTR2C | |
| SCHEMBL8258918 | 0.78 | PNMT (0.55) | PNMTADRA2AASIC3HTR2AHTR2C | |
| SCHEMBL20274100 | 0.78 | ALDH1A1 (0.57) | SIRT6SMN1; SMN2CA12CA9HTR2A | |
| SCHEMBL13362121 | 0.78 | ALDH1A1 (0.61) | SIRT6SMN1; SMN2CA12CA9HTR2A | |
| SCHEMBL24040085 | 0.77 | PNMT (0.54) | PNMTADRA2AASIC3HTR2AHTR2C | |
| SCHEMBL31335752 | 0.77 | MAPT (0.60) | PNMTADRA2AASIC3HTR2AHTR2C | |
| SCHEMBL24869958 | 0.77 | PNMT (0.54) | PNMTADRA2ASMN1; SMN2HTR2AHTR2C | |
| SCHEMBL417912 | 0.77 | MAPT (0.60) | PNMTADRA2AASIC3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548479-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102366-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |