Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20214503 | 1.00 | THRA (0.50) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL3912828 | 0.98 | THRA (0.51) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL5703040 | 0.98 | THRA (0.51) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL566676 | 0.97 | FDPS (0.51) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL566481 | 0.92 | FDPS (0.53) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL566342 | 0.88 | CSNK2A1 (0.55) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL14195856 | 0.87 | PTPN11 (0.48) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL25781297 | 0.87 | LMNA (0.54) | THRATHRBS1PR2S1PR1S1PR3 | |
| SCHEMBL10497979 | 0.84 | FDPS (0.63) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL2948173 | 0.84 | FDPS (0.63) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548492-A1 | CELL IMPERMEABLE COELENTERAZINE ANALOGUES | Promega Corporation (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102693-A1 | CELL IMPERMEABLE COELENTERAZINE ANALOGUES | PROMEGA CORPORATION (US) | 2018-06-07 | — | — | WO | disclosed |