Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121133 | 0.79 | ALDH1A1 (0.47) | TAS1R3TAS1R1TAS1R2LOXL2LMNA | |
| SCHEMBL820914 | 0.79 | MAPT (0.48) | ITGB3ITGA2BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12692656 | 0.78 | NLRP3 (0.44) | LOXL2LMNANLRP3CYP1A2CYP2C9 | |
| SCHEMBL820918 | 0.78 | HDAC1 (0.50) | TAS1R3TAS1R1LMNAALDH1A1 | |
| SCHEMBL820885 | 0.73 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL13008025 | 0.73 | NLRP3 (0.44) | NLRP3POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL820929 | 0.72 | EPHX2 (0.47) | LMNAITGB3ITGA2BPOLBCYP1A2 | |
| SCHEMBL7222675 | 0.72 | TSHR (0.53) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12121033 | 0.70 | LOXL2 (0.49) | LOXL2LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL14702328 | 0.70 | ALDH1A1 (0.47) | TAS1R3TAS1R1TAS1R2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102358-A1 | METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE | T3D THERAPEUTICS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |