Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217432 | 0.78 | KMT2A (0.47) | KDM4EHPGDMAPK1KMT2AMEN1 | |
| SCHEMBL20217329 | 0.68 | CYP3A4 (0.52) | KDM4EMAPK1KMT2AL3MBTL1LMNA | |
| SCHEMBL20217644 | 0.67 | KMT2A (0.45) | KDM4EMAPK1KMT2AMEN1L3MBTL1 | |
| SCHEMBL20217777 | 0.67 | KMT2A (0.49) | KDM4ETSHRMAPK1KMT2AL3MBTL1 | |
| SCHEMBL20217630 | 0.65 | RAB9A (0.45) | KDM4EHPGDMAPK1KMT2AMEN1 | |
| SCHEMBL13066428 | 0.61 | SMN1; SMN2 (0.51) | KDM4ETSHRHPGDMAPK1KMT2A | |
| SCHEMBL4964666 | 0.60 | KMT2A (0.67) | KDM4ETSHRHPGDMAPK1KMT2A | |
| SCHEMBL11625676 | 0.58 | LMNA (0.74) | KDM4EHPGDKMT2AMEN1L3MBTL1 | |
| SCHEMBL10353314 | 0.58 | TSHR (0.67) | KDM4ETSHRHPGDMAPK1KMT2A | |
| SCHEMBL30157827 | 0.58 | KMT2A (0.66) | KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |