Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.49 |
| ▸ | TTK | P33981 | 7/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.49 |
| ▸ | INCENP | Q9NQS7 | 7/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 5/20 | 0.31 |
| ▸ | HTR3A | P46098 | 2/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217484 | 0.86 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217662 | 0.84 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPKCNK3 | |
| SCHEMBL20217579 | 0.83 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217446 | 0.80 | CYP3A4 (0.53) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217956 | 0.80 | CYP3A4 (0.48) | CYP3A4TTKAURKBINCENPKCNK3 | |
| SCHEMBL20217481 | 0.79 | ALDH1A1 (0.38) | MEN1ALDH1A1KMT2A | |
| SCHEMBL20217912 | 0.78 | CYP3A4 (0.43) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217549 | 0.77 | CYP3A4 (0.49) | CYP3A4TTKAURKBINCENPHTR3A | |
| SCHEMBL20217462 | 0.77 | MAPT (0.38) | CYP3A4ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217145 | 0.77 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |