Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20388086 | 0.79 | NTRK1 (0.40) | HPGDMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL13698632 | 0.78 | RAB9A (0.60) | HPGDMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL20218054 | 0.77 | MAPT (0.42) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4179630 | 0.74 | HPGD (0.54) | HPGDMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL21622352 | 0.72 | ALOX5AP (0.38) | HPGDTP53MAPTLMNAPOLB | |
| SCHEMBL6355405 | 0.72 | CA12 (0.63) | SMN1; SMN2MAPTGRM6ALDH1A1KDM4E | |
| SCHEMBL20217955 | 0.71 | GRM1 (0.56) | — | |
| SCHEMBL15715950 | 0.70 | RAB9A (0.47) | HPGDMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL13860486 | 0.69 | NTRK1 (0.44) | HPGDMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL15715960 | 0.69 | RAB9A (0.49) | HPGDMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330256-B1 | HETEROCYCLIC DERIVATIVE HAVING TrkA-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2021-06-16 | — | — | EP | disclosed |
| US-10640495-B2 | Heterocycle derivatives having TrkA inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2020-05-05 | — | — | US | disclosed |
| US-20180201607-A1 | HETEROCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2018-07-19 | — | — | US | disclosed |
| US-20180201607-A1 | HETEROCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2018-07-19 | — | — | US | disclosed |
| EP-3330256-A1 | HETEROCYCLIC DERIVATIVE HAVING TrkA-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2018-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640495-B2 | Heterocycle derivatives having TrkA inhibitory activity | NTRK2, NR5A2, NTRK1 | HPGD 4282/4885MEN1 3241/4885KMT2A 1804/4885 |
| US-20180201607-A1 | HETEROCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | NTRK2, NR5A2, NTRK1 | HPGD 4282/4885MEN1 3241/4885KMT2A 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.