Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29184419 | 0.81 | PTPN11 (0.52) | PIK3CACKS1BSKP1SKP2GPR119 | |
| SCHEMBL21622377 | 0.78 | NTRK1 (0.43) | NTRK1PIK3R1POLBLMNAMAPT | |
| SCHEMBL15716244 | 0.77 | LMNA (0.40) | ALOX5APFEN1PIK3CAUSP30POLB | |
| SCHEMBL15716222 | 0.73 | USP30 (0.43) | USP30POLBGPR119TP53THRB | |
| SCHEMBL20217955 | 0.72 | GRM1 (0.56) | — | |
| SCHEMBL15716055 | 0.72 | OPRD1 (0.43) | USP30POLBGPR119TP53THRB | |
| SCHEMBL20218052 | 0.72 | HPGD (0.45) | POLBTP53LMNAMAPTHPGD | |
| SCHEMBL15716059 | 0.71 | GPR119 (0.40) | USP30POLBGPR119TP53THRB | |
| SCHEMBL21622271 | 0.71 | NR1H2 (0.41) | CKS1BSKP1SKP2USP30POLB | |
| SCHEMBL15715960 | 0.70 | RAB9A (0.49) | NTRK1PIK3R1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210147436-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2021-05-20 | — | — | US | disclosed |
| EP-3822266-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020011227-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | 南京明德新药研发有限公司 | 2020-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147436-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | NGF, RET, NTRK1 | ALOX5AP 3986/4885FEN1 4177/4885PIK3CA 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.