Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219768 | 0.88 | TLR7 (0.47) | TLR7TLR8L3MBTL1 | |
| SCHEMBL23472558 | 0.82 | DHFR (0.51) | — | |
| SCHEMBL23472595 | 0.82 | TLR8 (0.54) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219671 | 0.82 | DHFR (0.51) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219607 | 0.81 | TLR7 (0.52) | TLR7TLR8L3MBTL1 | |
| SCHEMBL13195740 | 0.80 | L3MBTL1 (0.57) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219619 | 0.79 | TLR7 (0.55) | TLR7TLR8 | |
| SCHEMBL23472257 | 0.78 | L3MBTL1 (0.58) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219488 | 0.78 | TLR7 (0.51) | TLR7TLR8L3MBTL1 | |
| SCHEMBL23472602 | 0.78 | TLR7 (0.47) | TLR7TLR8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |