Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219607 | 0.88 | TLR7 (0.52) | L3MBTL1TLR7TLR8 | |
| SCHEMBL20219369 | 0.87 | DHFR (0.50) | DHFRL3MBTL1TLR7TLR8 | |
| SCHEMBL23472595 | 0.85 | TLR8 (0.54) | L3MBTL1TLR7TLR8 | |
| SCHEMBL13195740 | 0.84 | L3MBTL1 (0.57) | L3MBTL1TLR7TLR8 | |
| SCHEMBL23472257 | 0.83 | L3MBTL1 (0.58) | L3MBTL1TLR7TLR8 | |
| SCHEMBL20219488 | 0.82 | TLR7 (0.51) | L3MBTL1TLR7TLR8 | |
| SCHEMBL20219655 | 0.82 | TLR8 (0.50) | L3MBTL1TLR7TLR8 | |
| SCHEMBL20219258 | 0.82 | TLR7 (0.44) | L3MBTL1TLR7TLR8 | |
| SCHEMBL20219263 | 0.82 | L3MBTL1 (0.48) | DHFRL3MBTL1TLR7TLR8 | |
| SCHEMBL20219619 | 0.81 | TLR7 (0.55) | DHFRTLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |