Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.35 |
| ▸ | MERTK | Q12866 | 4/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470139 | 0.85 | TLR7 (0.54) | GCKTLR8TLR7CYP1A2CYP3A4 | |
| SCHEMBL20219466 | 0.80 | TLR7 (0.42) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23472501 | 0.78 | TLR8 (0.38) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20219314 | 0.78 | CYP1A2 (0.39) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23472593 | 0.76 | CYP1A2 (0.43) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23472511 | 0.76 | CHRNB2 (0.43) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23472434 | 0.74 | CYP2D6 (0.40) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20219322 | 0.73 | CYP1A2 (0.42) | TLR8TLR7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20219579 | 0.73 | NPC1 (0.47) | CYP1A2CYP2D6MAPTMEN1ALDH1A1 | |
| SCHEMBL23472651 | 0.73 | NPC1 (0.47) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |