Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 11/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 11/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195755 | 1.00 | TRPM8 (0.40) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL23472142 | 0.90 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL19274227 | 0.90 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL15470343 | 0.90 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL23472645 | 0.87 | TRPM8 (0.40) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL23472604 | 0.86 | NUDT1 (0.41) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL20418783 | 0.84 | P2RX3 (0.36) | TRPM8NUDT1P2RX3P2RX2SMN1; SMN2 | |
| SCHEMBL13195079 | 0.83 | NUDT1 (0.43) | TRPM8NUDT1P2RX3P2RX2SMN1; SMN2 | |
| SCHEMBL21769311 | 0.81 | TRPM8 (0.46) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL15469992 | 0.80 | TLR8 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |