Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472142 | 0.88 | TRPM8 (0.44) | TRPM8KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL15470343 | 0.88 | TRPM8 (0.44) | TRPM8KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL19274227 | 0.88 | TRPM8 (0.44) | TRPM8KCNH2TLR8TLR7CYP2D6 | |
| SCHEMBL20386620 | 0.80 | TRPM8 (0.32) | TRPM8TLR8TLR7 | |
| SCHEMBL23472645 | 0.78 | TRPM8 (0.40) | TRPM8TLR8TLR7NUDT1 | |
| SCHEMBL20219325 | 0.78 | TRPM8 (0.40) | TRPM8NUDT1 | |
| SCHEMBL13195755 | 0.78 | TRPM8 (0.40) | TRPM8NUDT1 | |
| SCHEMBL21769311 | 0.77 | TRPM8 (0.46) | TRPM8TLR8TLR7CYP2D6DRD1 | |
| SCHEMBL23472223 | 0.75 | TRPM8 (0.45) | TRPM8TLR8TLR7 | |
| SCHEMBL23472485 | 0.75 | TRPM8 (0.45) | TRPM8TLR8TLR7CYP2D6DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |