Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 6/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15469788 | 1.00 | TRPM8 (0.45) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL21769311 | 0.92 | TRPM8 (0.46) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL23472604 | 0.90 | NUDT1 (0.41) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL15470343 | 0.86 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL19274227 | 0.86 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL23472142 | 0.86 | TRPM8 (0.44) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL15469787 | 0.80 | TRPM8 (0.45) | TRPM8NUDT1P2RX3P2RX2TLR7 | |
| SCHEMBL20219325 | 0.79 | TRPM8 (0.40) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL13195755 | 0.79 | TRPM8 (0.40) | TRPM8NUDT1P2RX3P2RX2MITF | |
| SCHEMBL20219312 | 0.79 | CYP2D6 (0.56) | TLR7TLR8CYP2D6DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |