Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CX3CR1 | P49238 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20413269 | 0.90 | CX3CR1 (0.42) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL15469787 | 0.86 | TRPM8 (0.45) | TRPM8TLR7TLR8CYP2D6DRD1 | |
| SCHEMBL20413303 | 0.79 | TLR7 (0.37) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL20413265 | 0.79 | CRHR1 (0.43) | TRPM8MAPTSMN1; SMN2POLB | |
| SCHEMBL23472223 | 0.79 | TRPM8 (0.45) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17208883 | 0.76 | TRPM8 (0.55) | TRPM8MITFLMNAMAPTSMN1; SMN2 | |
| SCHEMBL15469950 | 0.75 | CX3CR1 (0.44) | TRPM8CX3CR1CXCR2TLR7TLR8 | |
| SCHEMBL23472478 | 0.74 | TLR7 (0.41) | TRPM8TLR7TLR8CYP2D6DRD1 | |
| SCHEMBL20219370 | 0.74 | CYP2D6 (0.40) | TLR7TLR8CYP2D6DRD1HTR2A | |
| SCHEMBL20413293 | 0.74 | CYP2D6 (0.40) | TLR7TLR8CYP2D6DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |