Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195105 | 0.87 | STK17B (0.42) | MERTKSTK17BSTK17ABRD4TYRO3 | |
| SCHEMBL15469749 | 0.85 | MERTK (0.41) | MERTKSTK17BSTK17ABRD4TYRO3 | |
| SCHEMBL15469750 | 0.84 | LMNA (0.40) | MERTKSTK17BSTK17ATYRO3GAS6 | |
| SCHEMBL15469746 | 0.81 | TLR8 (0.41) | MERTKSTK17BSTK17ATYRO3GAS6 | |
| SCHEMBL15469709 | 0.76 | CYP2D6 (0.42) | MERTKSTK17BSTK17ATYRO3GAS6 | |
| SCHEMBL22915542 | 0.74 | MERTK (0.40) | MERTKTYRO3GAS6FLT3TLR8 | |
| SCHEMBL21769127 | 0.73 | MERTK (0.36) | MERTKSTK17BSTK17ATYRO3GAS6 | |
| SCHEMBL22915538 | 0.71 | LMNA (0.34) | MERTKTYRO3GAS6FLT3AXL | |
| SCHEMBL20219452 | 0.68 | TYRO3 (0.39) | MERTKBRD4TYRO3GAS6JAK3 | |
| SCHEMBL13195074 | 0.66 | L3MBTL1 (0.52) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |