Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 9/20 | 0.34 |
| ▸ | AQP1 | P29972 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15469750 | 0.86 | LMNA (0.40) | LMNASMN1; SMN2STAT3MERTKKDM6B | |
| SCHEMBL15469749 | 0.85 | MERTK (0.41) | MERTKTYRO3GAS6FLT3CA12 | |
| SCHEMBL21769127 | 0.76 | MERTK (0.36) | MERTKTYRO3AXLGAS6FLT3 | |
| SCHEMBL13195105 | 0.73 | STK17B (0.42) | MERTKTYRO3AXLGAS6FLT3 | |
| SCHEMBL13195834 | 0.71 | L3MBTL1 (0.47) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20219443 | 0.71 | MERTK (0.39) | MERTKTYRO3AXLGAS6FLT3 | |
| SCHEMBL20219572 | 0.70 | CYP2D6 (0.43) | LMNASMN1; SMN2STAT3KDM6BKDM4C | |
| SCHEMBL15469746 | 0.70 | TLR8 (0.41) | SMN1; SMN2MERTKTYRO3GAS6FLT3 | |
| SCHEMBL22915542 | 0.67 | MERTK (0.40) | LMNASMN1; SMN2MERTKTYRO3AXL | |
| SCHEMBL15469709 | 0.65 | CYP2D6 (0.42) | MERTKTYRO3AXLGAS6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541050-B2 | Pyrimidine derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2023-01-03 | — | — | US | disclosed |
| US-20210023082-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541050-B2 | Pyrimidine derivatives for the treatment of viral infections | TYMP, UMPS, HPRT1 | LMNA 3150/4885SMN1; SMN2 3359/4885STAT3 2401/4885 |
| US-20210023082-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMP, UMPS, HPRT1 | LMNA 3150/4885SMN1; SMN2 3359/4885STAT3 2401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.