Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219506 | 0.98 | SRC (0.44) | LMNASMN1; SMN2S1PR2NPSR1SRC | |
| SCHEMBL15469957 | 0.81 | TLR8 (0.47) | CYP1A2TLR8CYP2D6 | |
| SCHEMBL23472189 | 0.80 | TLR8 (0.41) | NPSR1SRCABL1ALDH1A1TSHR | |
| SCHEMBL20219679 | 0.79 | TLR8 (0.40) | LMNASMN1; SMN2NPSR1SRCABL1 | |
| SCHEMBL15469963 | 0.79 | TLR8 (0.50) | CYP1A2TLR8CYP2D6 | |
| SCHEMBL13195744 | 0.79 | TLR8 (0.50) | CYP1A2TLR8CYP2D6 | |
| SCHEMBL15469961 | 0.79 | TLR8 (0.50) | CYP1A2TLR8CYP2D6 | |
| SCHEMBL23472446 | 0.76 | TLR8 (0.39) | LMNASMN1; SMN2NPSR1SRCABL1 | |
| SCHEMBL23472328 | 0.74 | SRC (0.45) | LMNASMN1; SMN2S1PR2NPSR1SRC | |
| SCHEMBL20219716 | 0.74 | SRC (0.45) | LMNASMN1; SMN2S1PR2NPSR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |