Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.41 |
| ▸ | STK17B | O94768 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472334 | 0.87 | TLR8 (0.43) | TLR8TLR7STK17ASTK17BKDM4E | |
| SCHEMBL15469985 | 0.87 | TLR8 (0.54) | TLR8TLR7STK17ASTK17BL3MBTL1 | |
| SCHEMBL23472518 | 0.87 | TLR7 (0.45) | TLR8TLR7STK17ASMN1; SMN2 | |
| SCHEMBL20219479 | 0.84 | TLR7 (0.41) | TLR8TLR7STK17ASTK17BL3MBTL1 | |
| SCHEMBL23472263 | 0.84 | S1PR4 (0.47) | STK17AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL23472323 | 0.84 | TLR8 (0.54) | TLR8TLR7ALDH1A1 | |
| SCHEMBL23472190 | 0.84 | TLR7 (0.41) | TLR8TLR7STK17ASTK17BALDH1A1 | |
| SCHEMBL20219583 | 0.81 | TLR8 (0.44) | TLR8TLR7STK17ASTK17BKDM4E | |
| SCHEMBL23472288 | 0.81 | TLR8 (0.38) | TLR8TLR7KDM4ESMN1; SMN2CRHR1 | |
| SCHEMBL23472163 | 0.81 | TLR7 (0.49) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |