Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472190 | 0.91 | TLR7 (0.41) | TLR7TLR8L3MBTL1STK17ASTK17B | |
| SCHEMBL23472284 | 0.88 | TLR7 (0.50) | TLR7TLR8L3MBTL1 | |
| SCHEMBL20219489 | 0.84 | TLR8 (0.44) | TLR7TLR8L3MBTL1STK17ASTK17B | |
| SCHEMBL23472518 | 0.83 | TLR7 (0.45) | TLR7TLR8STK17A | |
| SCHEMBL15470073 | 0.81 | TLR7 (0.52) | TLR7TLR8L3MBTL1MCHR1 | |
| SCHEMBL20219328 | 0.81 | ATP4A (0.39) | TLR7TLR8 | |
| SCHEMBL20219397 | 0.81 | TLR7 (0.48) | TLR7TLR8L3MBTL1 | |
| SCHEMBL23472323 | 0.80 | TLR8 (0.54) | TLR7TLR8 | |
| SCHEMBL20219381 | 0.78 | TLR8 (0.34) | TLR7TLR8L3MBTL1 | |
| SCHEMBL23472288 | 0.78 | TLR8 (0.38) | TLR7TLR8L3MBTL1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |