Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219304 | 0.87 | TLR8 (0.36) | TLR8TLR7CYP3A4L3MBTL1CRHR1 | |
| SCHEMBL23472323 | 0.86 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL23472526 | 0.85 | TLR8 (0.47) | TLR8TLR7CYP3A4L3MBTL1NPSR1 | |
| SCHEMBL23472109 | 0.85 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1NPSR1 | |
| SCHEMBL13195679 | 0.84 | L3MBTL1 (0.54) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219572 | 0.83 | CYP2D6 (0.43) | TLR8TLR7CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL20219723 | 0.83 | ALDH1A1 (0.38) | TLR8TLR7CRHR1 | |
| SCHEMBL20219396 | 0.83 | TLR8 (0.35) | TLR8TLR7CYP3A4L3MBTL1NPSR1 | |
| SCHEMBL13195077 | 0.82 | L3MBTL1 (0.56) | TLR8TLR7L3MBTL1 | |
| SCHEMBL20219386 | 0.82 | SCN9A (0.36) | TLR8TLR7CYP3A4L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |