Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20219257 | 0.90 | SIGMAR1 (0.41) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL15469987 | 0.88 | TLR7 (0.50) | TLR8TLR7CCR4 | |
| SCHEMBL20219252 | 0.86 | CXCR2 (0.42) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219688 | 0.85 | TLR8 (0.39) | TLR8TLR7CCR4TRPM8PTGES | |
| SCHEMBL20219329 | 0.84 | SIGMAR1 (0.41) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472338 | 0.83 | TLR8 (0.39) | TLR8TLR7CCR4PTGESALOX5 | |
| SCHEMBL23472079 | 0.83 | TLR8 (0.47) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219393 | 0.80 | TLR8 (0.38) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472323 | 0.78 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL15469989 | 0.77 | TLR8 (0.48) | TLR8TLR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |