Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472676 | 0.95 | PPARG (0.40) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472598 | 0.86 | TLR8 (0.43) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472561 | 0.84 | TLR8 (0.48) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219252 | 0.83 | CXCR2 (0.42) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219279 | 0.83 | TLR8 (0.35) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472283 | 0.82 | TLR7 (0.45) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219257 | 0.81 | SIGMAR1 (0.41) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472079 | 0.80 | TLR8 (0.47) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL23472523 | 0.80 | TLR7 (0.50) | TLR8TLR7 | |
| SCHEMBL20219554 | 0.80 | TLR8 (0.41) | TLR8TLR7PTGESALOX5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |