Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472079 | 0.95 | TLR8 (0.47) | CXCR2CX3CR1TLR8TLR7CDK1 | |
| SCHEMBL20219257 | 0.93 | SIGMAR1 (0.41) | TLR8TLR7SIGMAR1PTGESALOX5 | |
| SCHEMBL20219323 | 0.88 | TLR8 (0.49) | CXCR2CX3CR1TLR8TLR7KCNH2 | |
| SCHEMBL15470008 | 0.88 | TLR8 (0.49) | CXCR2CX3CR1TLR8TLR7KCNH2 | |
| SCHEMBL20219329 | 0.86 | SIGMAR1 (0.41) | TLR8TLR7SIGMAR1PTGESALOX5 | |
| SCHEMBL20219554 | 0.86 | TLR8 (0.41) | TLR8TLR7SIGMAR1PTGESALOX5 | |
| SCHEMBL15470074 | 0.83 | TLR8 (0.56) | TLR8TLR7CDK1CDK5KCNH2 | |
| SCHEMBL20219393 | 0.83 | TLR8 (0.38) | TLR8TLR7PTGESALOX5PPARG | |
| SCHEMBL20219289 | 0.83 | TLR8 (0.56) | TLR8TLR7CDK1CDK5KCNH2 | |
| SCHEMBL20413264 | 0.82 | CRHR1 (0.40) | TLR8TLR7CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |