Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472411 | 0.78 | TLR7 (0.47) | TLR7TLR8KCNH2 | |
| SCHEMBL20386791 | 0.74 | KCNH2 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL20219648 | 0.71 | TLR8 (0.43) | TLR7TLR8KCNH2 | |
| SCHEMBL23472276 | 0.69 | TLR7 (0.37) | TLR7TLR8 | |
| SCHEMBL20386690 | 0.69 | TLR7 (0.37) | TLR7TLR8 | |
| SCHEMBL20219712 | 0.67 | TLR8 (0.46) | TLR7TLR8KCNH2 | |
| SCHEMBL20219258 | 0.66 | TLR7 (0.44) | TLR7TLR8 | |
| SCHEMBL23472420 | 0.66 | CYP2D6 (0.39) | TLR7TLR8KCNH2 | |
| SCHEMBL20413288 | 0.65 | HPGD (0.39) | TLR7TLR8KCNH2 | |
| SCHEMBL23472609 | 0.64 | KCNH2 (0.37) | TLR7TLR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |