Sugi Predict

Sugi Predict / Compounds / SCHEMBL20226554

SCHEMBL20226554

SCHEMBL20226554

CS(=O)(=O)c1c(F)c(F)c(N)c(F)c1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 12/20 0.42
▸ CA2 P00918 12/20 0.42
▸ CA12 O43570 9/20 0.42
▸ CA7 P43166 9/20 0.42
▸ CA13 Q8N1Q1 9/20 0.42
▸ CA9 Q16790 3/20 0.35
▸ F2 P00734 3/20 0.33
▸ PRSS1 P07477 3/20 0.33
▸ PRSS2 P07478 3/20 0.33
▸ PRSS3 P35030 3/20 0.33
▸ MMP1 P03956 1/20 0.32
▸ MMP2 P08253 1/20 0.32
▸ MMP9 P14780 1/20 0.32
▸ MMP8 P22894 1/20 0.32
▸ MMP13 P45452 1/20 0.32
▸ CA3 P07451 2/20 0.31
▸ CA4 P22748 2/20 0.31
▸ CA6 P23280 2/20 0.31
▸ CA5A P35218 2/20 0.31
▸ CA14 Q9ULX7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1457197 0.92 CA1 (0.40) CA1CA2CA12CA7CA13
SCHEMBL6036996 0.90 CA1 (0.36) CA1CA2CA12CA7CA13
SCHEMBL12433063 0.86 CA1 (0.45) CA1CA2CA12CA7CA13
SCHEMBL777917 0.83 CA1 (0.50) CA1CA2CA12CA7CA13
SCHEMBL7868522 0.78 CA1 (0.46) CA1CA2CA12CA7CA13
SCHEMBL15647727 0.76 CA1 (0.74) CA1CA2CA12CA7CA13
SCHEMBL107769 0.76 CA1 (0.38) CA1CA2CA12CA7CA13
SCHEMBL20226553 0.75 CA1 (0.41) CA1CA2CA12CA7CA13
SCHEMBL8154017 0.74 CA1 (0.42) CA1CA2CA12CA7CA13
SCHEMBL2759901 0.74 CA1 (0.39) CA1CA2CA12CA7CA13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024175998-A1 BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF DUNAD THERAPEUTICS, LTD. (GB) 2024-08-29 — — WO disclosed
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 — — US disclosed
US-20210040144-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2021-02-11 — — US disclosed
US-10711032-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. (US) 2020-07-14 — — US disclosed
WO-2018089373-A9 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2018-07-12 — — WO disclosed
US-20180155389-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2018-06-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180155389-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF SERPINA6, NR3C1, NR3C2 CA1 3880/4885CA2 4541/4885CA12 3431/4885
US-10711032-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 CA1 3880/4885CA2 4541/4885CA12 3431/4885
US-20210040144-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF SERPINA6, NR3C1, NR3C2 CA1 3944/4885CA2 4533/4885CA12 3598/4885
US-11760775-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 CA1 3944/4885CA2 4533/4885CA12 3598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.