Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7772483 | 0.81 | LMNA (0.70) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL2024165 | 0.80 | LMNA (0.51) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL13280038 | 0.80 | KMT2A (0.51) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL6464286 | 0.79 | KMT2A (0.50) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL17747485 | 0.79 | ALDH1A1 (0.76) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL29408315 | 0.78 | SMN1; SMN2 (0.44) | ALDH1A1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL4918939 | 0.76 | KMT2A (0.48) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL6465905 | 0.75 | ALDH1A1 (0.75) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL6465337 | 0.75 | KMT2A (0.72) | ALDH1A1KMT2APOLBLMNAGAA | |
| SCHEMBL9639864 | 0.75 | GFER (0.52) | ALDH1A1KMT2APOLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512466-A1 | PRODRUGS OF INHIBITORS OF PLASMA KALLIKREIN | Activesite Pharmaceuticals, Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075684-A1 | PRODRUGS OF INHIBITORS OF PLASMA KALLIKREIN | ACTIVESITE PHARMACEUTICALS, INC. (US) | 2011-06-23 | — | — | WO | disclosed |