Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517260 | 0.84 | CHRM2 (0.54) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL1758 | 0.83 | HDAC4 (0.51) | OPRM1CHRM2CHRM1 | |
| SCHEMBL7385128 | 0.82 | SLC6A3 (0.47) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL7047849 | 0.82 | SLC6A3 (0.47) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL16506943 | 0.82 | SLC6A3 (0.55) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL1350 | 0.80 | SLC6A4 (0.49) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL16521044 | 0.79 | SLC6A3 (0.47) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL7366120 | 0.79 | CHRM2 (0.49) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 | |
| SCHEMBL13070452 | 0.78 | OPRM1 (0.48) | OPRM1 | |
| SCHEMBL16507659 | 0.78 | SLC6A4 (0.48) | OPRM1SLC6A4SLC6A3SLC6A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |
| US-4629727-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0111994-B1 | (1-ARYLCYCLOBUTYL) ALKYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | disclosed |
| EP-0111994-A1 | (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents | The Boots Company PLC (GB) | 1984-06-27 | — | — | EP | disclosed |