SCHEMBL2023385

SCHEMBL2023385

COc1ccc(O)c2c(O)c(C(C)=O)c(C)cc12

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.51
MAPT P10636 3/20 0.51
CYP3A4 P08684 2/20 0.50
MAPK1 P28482 2/20 0.46
USP2 O75604 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HTT P42858 1/20 0.42
LMNA P02545 1/20 0.40
ALDH1A1 P00352 1/20 0.39
APP P05067 1/20 0.39
SYNJ2 O15056 1/20 0.38
SLC22A6 Q4U2R8 1/20 0.38
SLC22A8 Q8TCC7 1/20 0.38
HIF1A Q16665 1/20 0.38
EPAS1 Q99814 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2023742 0.87 PIM1 (0.40) GAAMAPTCYP3A4HTTALDH1A1
SCHEMBL16226897 0.76 CYP3A4 (0.56) GAAMAPTCYP3A4MAPK1USP2
SCHEMBL23190743 0.76 CYP3A4 (0.55) GAAMAPTCYP3A4MAPK1USP2
SCHEMBL3193234 0.76 CYP3A4 (0.55) GAAMAPTCYP3A4MAPK1USP2
SCHEMBL29429335 0.76 CYP3A4 (0.55) GAAMAPTCYP3A4MAPK1USP2
SCHEMBL9617423 0.75 IDO1 (0.48) GAACYP3A4MAPK1USP2SMN1; SMN2
SCHEMBL29664473 0.74 CYP3A4 (0.58) GAAMAPTCYP3A4MAPK1USP2
SCHEMBL20020937 0.73 MAPT (0.47) GAAMAPTCYP3A4LMNA
SCHEMBL7780857 0.73 MAPT (0.49) GAAMAPTCYP3A4MAPK1SMN1; SMN2
Isotorachrysone SCHEMBL16226209 0.72 CYP3A4 (0.47) MAPTCYP3A4MAPK1USP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073151-A2 METHOD FOR THE TWO-STEP DYEING OF KERATIN FIBRES, BY APPLICATION OF A COMPOSITION COMPRISING A NAPHTALENE DERIVATIVE, THEN ALKALINE TREATMENT. L'OREAL (FR) 2011-06-23 WO claimed
EP-0850635-B1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set OREAL (FR) 1999-07-14 EP claimed
EP-2612847-A1 RECORDING MATERIAL USING PHENOL COMPOUND Nippon Soda Co., Ltd. (JP) 2013-07-10 EP disclosed
WO-2011073151-A2 METHOD FOR THE TWO-STEP DYEING OF KERATIN FIBRES, BY APPLICATION OF A COMPOSITION COMPRISING A NAPHTALENE DERIVATIVE, THEN ALKALINE TREATMENT. L'OREAL (FR) 2011-06-23 WO disclosed
EP-1555993-B1 PERMANENT COLORING OF HAIR USING AN OXIDATION HAIR DYE PRECURSOR AND A METAL CYANATE UNILEVER PLC (GB) 2010-03-24 EP disclosed
EP-1555993-A2 PERMANENT COLORING OF HAIR USING AN OXIDATION HAIR DYE PRECURSOR AND A METAL CYANATE UNILEVER PLC (GB) 2005-07-27 EP disclosed
US-6821302-B2 Oxidation color dye comprising a metal cyanate, free of ammonia, without the pungent odor of ammonia UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-11-23 US disclosed
US-6758866-B2 AQUEOUS SOLUTION OF CHELATE COMPOUND, OXIDATION COLOR DYE AND COUPLER UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-07-06 US disclosed
WO-2004039341-A2 PERMANENT COLORING OF HAIR USING AN OXIDATION HAIR DYE PRECURSOR AND A METAL CYANATE UNILEVER PLC (GB) 2004-05-13 WO disclosed
US-20040083557-A1 Permanent coloring of hair using carbonate salts and bicarbonate salts and using percarbamic acid precursors UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-05-06 US disclosed
US-20040019980-A1 One step hair coloring compositions using salts UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-02-05 US disclosed
US-20030135935-A1 Enhanced color deposition for hair with sequestering agents UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-07-24 US disclosed
EP-0850635-B1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set OREAL (FR) 1999-07-14 EP disclosed
US-5873910-A IN FIRST STAGE APPLYING TO KERATIN FIBER A FIRST SOLUTION CONTAINING IN A DYEING MEDIUM A MANGANESE SALT AND/OR COMPLEX, IN SECOND STAGE, APPLYING TO THE HAIR A SOLUTION WHICH CONTAINS 4-SUBSTITUED NAPHTHOL/1-/ AND AN OXIDIZER L'OREAL (FR) 1999-02-23 US disclosed