SCHEMBL2023742

SCHEMBL2023742

CC(=O)Oc1ccc(O)c2c(O)c(C(C)=O)c(C)cc12

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 0.40
GAA P10253 4/20 0.39
KDM4E B2RXH2 4/20 0.39
HTT P42858 3/20 0.39
MAPT P10636 3/20 0.39
TP53 P04637 1/20 0.39
HSD17B10 Q99714 1/20 0.39
POLB P06746 2/20 0.38
ACHE P22303 1/20 0.37
ALDH1A1 P00352 2/20 0.36
TSHR P16473 1/20 0.36
RAB9A P51151 1/20 0.36
CYP3A4 P08684 1/20 0.36
CFD P00746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2023385 0.87 GAA (0.51) GAAHTTMAPTALDH1A1CYP3A4
SCHEMBL3164738 0.83 AKT1 (0.40) PIM1GAAKDM4EHTTMAPT
SCHEMBL2025324 0.73 PIM1 (0.39) PIM1GAAKDM4EMAPTHSD17B10
Nepodin SCHEMBL1673268 0.68 MEN1 (0.53) GAAKDM4EMAPTTP53HSD17B10
Nepodin SCHEMBL30189621 0.68 MEN1 (0.53) GAAKDM4EMAPTTP53HSD17B10
SCHEMBL3994781 0.68 PIM1 (0.51) PIM1GAAKDM4EHTTMAPT
SCHEMBL3174222 0.67 MAPT (0.55) PIM1GAAKDM4EHTTMAPT
SCHEMBL27842430 0.66 ESR1 (0.53) PIM1GAAKDM4EHTTMAPT
SCHEMBL12332901 0.66 CFD (0.53) PIM1GAAKDM4EHTTMAPT
SCHEMBL7538049 0.66 PIM1 (0.53) PIM1GAAKDM4EHTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073151-A2 METHOD FOR THE TWO-STEP DYEING OF KERATIN FIBRES, BY APPLICATION OF A COMPOSITION COMPRISING A NAPHTALENE DERIVATIVE, THEN ALKALINE TREATMENT. L'OREAL (FR) 2011-06-23 WO claimed
EP-0850635-B1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set OREAL (FR) 1999-07-14 EP claimed
EP-0850635-A1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set L'OREAL (FR) 1998-07-01 EP claimed
WO-2011073151-A2 METHOD FOR THE TWO-STEP DYEING OF KERATIN FIBRES, BY APPLICATION OF A COMPOSITION COMPRISING A NAPHTALENE DERIVATIVE, THEN ALKALINE TREATMENT. L'OREAL (FR) 2011-06-23 WO disclosed
EP-1555993-A2 PERMANENT COLORING OF HAIR USING AN OXIDATION HAIR DYE PRECURSOR AND A METAL CYANATE UNILEVER PLC (GB) 2005-07-27 EP disclosed
US-6821302-B2 Oxidation color dye comprising a metal cyanate, free of ammonia, without the pungent odor of ammonia UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-11-23 US disclosed
WO-2004039341-A2 PERMANENT COLORING OF HAIR USING AN OXIDATION HAIR DYE PRECURSOR AND A METAL CYANATE UNILEVER PLC (GB) 2004-05-13 WO disclosed
US-20040083557-A1 Permanent coloring of hair using carbonate salts and bicarbonate salts and using percarbamic acid precursors UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-05-06 US disclosed
US-20040019980-A1 One step hair coloring compositions using salts UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-02-05 US disclosed
WO-2003053386-A1 ENHANCED COLOUR DEPOSITION FOR HAIR WITH SEQUESTERING AGENTS UNILEVER PLC (GB) 2003-07-03 WO disclosed
EP-0850635-B1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set OREAL (FR) 1999-07-14 EP disclosed
US-5873910-A IN FIRST STAGE APPLYING TO KERATIN FIBER A FIRST SOLUTION CONTAINING IN A DYEING MEDIUM A MANGANESE SALT AND/OR COMPLEX, IN SECOND STAGE, APPLYING TO THE HAIR A SOLUTION WHICH CONTAINS 4-SUBSTITUED NAPHTHOL/1-/ AND AN OXIDIZER L'OREAL (FR) 1999-02-23 US disclosed
EP-0850635-A1 Process for oxydative dyeing of keratinic fibers in two steps with a manganese salt or a manganese complex and a 1-naphtol substituted in position 4 and a dyeing set L'OREAL (FR) 1998-07-01 EP disclosed