Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239192 | 0.93 | OPRM1 (0.40) | ACACBSMN1; SMN2ALDH1A1DGAT2OPRM1 | |
| SCHEMBL20259192 | 0.91 | DGAT2 (0.47) | ACACBSMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL20239151 | 0.90 | SMN1; SMN2 (0.45) | ACACBSMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL20259256 | 0.88 | IGF1R (0.37) | SMN1; SMN2DGAT2OPRM1OPRD1OPRK1 | |
| SCHEMBL20239167 | 0.87 | SMN1; SMN2 (0.49) | ACACBSMN1; SMN2ALDH1A1MTNR1AMTNR1B | |
| SCHEMBL20239175 | 0.85 | DGAT2 (0.42) | SMN1; SMN2ALDH1A1DGAT2OPRM1OPRD1 | |
| SCHEMBL20259074 | 0.84 | DGAT2 (0.41) | SMN1; SMN2ALDH1A1DGAT2LMNAMAPT | |
| SCHEMBL20239173 | 0.84 | SMN1; SMN2 (0.46) | ACACBSMN1; SMN2ALDH1A1DGAT2OPRM1 | |
| SCHEMBL20239244 | 0.84 | DGAT2 (0.48) | ACACBALDH1A1DGAT2OPRM1OPRD1 | |
| SCHEMBL20239232 | 0.83 | DGAT2 (0.46) | ACACBSMN1; SMN2DGAT2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10053429-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | ACACB 152/4885SMN1; SMN2 4828/4885ALDH1A1 1430/4885 |
| US-10053429-B2 | DGAT2 inhibitors | DGAT2, DGAT1, LCAT | ACACB 152/4885SMN1; SMN2 4835/4885ALDH1A1 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.