Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239208 | 0.87 | DGAT2 (0.53) | DGAT2PGRPTK2LTA4HKCNH2 | |
| SCHEMBL20239246 | 0.86 | DGAT2 (0.50) | DGAT2PGRPTK2LTA4HKCNH2 | |
| SCHEMBL20239257 | 0.85 | DGAT2 (0.67) | DGAT2METRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL20239200 | 0.80 | DGAT2 (0.76) | DGAT2LTA4HKCNH2GRIN1GRIN2B | |
| SCHEMBL20239364 | 0.79 | DGAT2 (0.62) | DGAT2PTK2METSMN1; SMN2MAPT | |
| SCHEMBL20239321 | 0.78 | DGAT2 (0.46) | DGAT2PGRPTK2LTA4HKCNH2 | |
| SCHEMBL20239141 | 0.76 | DGAT2 (0.42) | DGAT2PGRPTK2LTA4HKCNH2 | |
| SCHEMBL20239338 | 0.76 | SMN1; SMN2 (0.46) | DGAT2PGRPTK2LTA4HKCNH2 | |
| SCHEMBL20239226 | 0.73 | DGAT2 (0.53) | DGAT2KCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20239204 | 0.72 | DGAT2 (0.69) | DGAT2METNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | DGAT2 1/4885PGR 2121/4885PTK2 4077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.