Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239338 | 0.90 | SMN1; SMN2 (0.46) | DGAT2PGRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20239175 | 0.86 | DGAT2 (0.42) | DGAT2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20239140 | 0.85 | DGAT2 (0.58) | DGAT2NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL20239182 | 0.84 | DGAT2 (0.47) | DGAT2PGRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20259074 | 0.81 | DGAT2 (0.41) | DGAT2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20239331 | 0.81 | PGR (0.43) | PGRNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL20239215 | 0.81 | PGR (0.37) | PGRNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL16747500 | 0.80 | DGAT2 (0.52) | DGAT2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20239192 | 0.79 | OPRM1 (0.40) | DGAT2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20239241 | 0.79 | ACACB (0.44) | DGAT2SMN1; SMN2HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | DGAT2 1/4885PGR 2121/4885NPC1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.