Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.65 |
| ▸ | TNF | P01375 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640621 | 0.86 | CYP11B1 (0.65) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL2028857 | 0.85 | CYP11B1 (0.61) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL13907295 | 0.84 | CYP11B1 (0.89) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL7029418 | 0.83 | PKM (0.62) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL4748504 | 0.83 | PKM (0.77) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL28277975 | 0.80 | ALDH1A1 (0.60) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL230002 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL31357411 | 0.80 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFSMN1; SMN2HTT | |
| SCHEMBL4831193 | 0.80 | KCNH2 (0.67) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL15486918 | 0.79 | BRD4 (0.52) | CYP11B1CYP11B2TNFSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516405-B1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | VIROSTATICS S R L (IT) | 2015-09-30 | — | — | EP | disclosed |
| EP-2516405-B1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | VIROSTATICS S R L (IT) | 2015-09-30 | — | — | EP | disclosed |
| US-9040529-B2 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2015-05-26 | — | — | US | disclosed |
| US-9040529-B2 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2015-05-26 | — | — | US | disclosed |
| US-9040529-B2 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2015-05-26 | — | — | US | disclosed |
| EP-2516405-A1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | Vichem Chemie Kutató KFT (HU) | 2012-10-31 | — | — | EP | disclosed |
| US-20120258968-A1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | VIROSTATICS S.R.L. (IT) | 2012-10-11 | — | — | US | disclosed |
| US-20120258968-A1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | VIROSTATICS S.R.L. (IT) | 2012-10-11 | — | — | US | disclosed |
| WO-2011077171-A1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258968-A1 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES HAVING PROTEIN KINASE INHIBITOR ACTIVITY | CDK9, CDK19, CDKL3 | CYP11B1 3699/4885CYP11B2 4147/4885TNF 1608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.