Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239196 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAALDH1A1GLAMTNR1A | |
| SCHEMBL20239137 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL20239293 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAMAPTALDH1A1MTNR1A | |
| SCHEMBL20239351 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBMAPTGLAMTNR1A | |
| SCHEMBL20239167 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTPOLBALDH1A1 | |
| SCHEMBL20239236 | 0.78 | POLB (0.49) | SMN1; SMN2LMNAHTTPOLBMAPT | |
| SCHEMBL20239138 | 0.76 | EPHX2 (0.43) | SMN1; SMN2LMNAHTTPOLBMAPT | |
| SCHEMBL20252445 | 0.75 | POLB (0.46) | SMN1; SMN2LMNAHTTPOLBMAPT | |
| SCHEMBL659053 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAALDH1A1GLAMTNR1A | |
| SCHEMBL20239189 | 0.72 | RAB9A (0.46) | SMN1; SMN2POLBMAPTALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10053429-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | SMN1; SMN2 4828/4885LMNA 2022/4885HTT 1239/4885 |
| US-10053429-B2 | DGAT2 inhibitors | DGAT2, DGAT1, LCAT | SMN1; SMN2 4835/4885LMNA 1722/4885HTT 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.