SCHEMBL202432

SCHEMBL202432

Cc1nc2ccc(Oc3ccccc3)cc2s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 1.00
L3MBTL1 Q9Y468 1/20 1.00
SMN1; SMN2 Q16637 8/20 0.68
NPC1 O15118 7/20 0.68
RAB9A P51151 7/20 0.68
MAPT P10636 5/20 0.68
HTT P42858 4/20 0.68
TP53 P04637 2/20 0.68
KMT2A Q03164 3/20 0.62
SCN4A P35499 1/20 0.54
SCN9A Q15858 1/20 0.54
MEN1 O00255 2/20 0.48
RXFP1 Q9HBX9 1/20 0.48
FSCN1 Q16658 1/20 0.47
HPGD P15428 2/20 0.47
ALDH1A1 P00352 2/20 0.47
PKM P14618 1/20 0.47
HSD17B10 Q99714 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2706157 0.87 TDP1 (0.77) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL14375385 0.86 TDP1 (0.75) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL11108189 0.82 MAPT (0.69) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL26691598 0.81 TDP1 (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL22208955 0.81 TDP1 (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL22209093 0.81 TDP1 (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL22224082 0.81 TDP1 (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL26691573 0.81 TDP1 (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL7285684 0.81 RAB9A (1.00) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL11109981 0.81 MAPT (0.68) TDP1L3MBTL1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
EP-1706398-B1 Amino-benzazoles as P2Y1 receptor inhibitors BRISTOL MYERS SQUIBB CO (US) 2014-05-21 EP disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-7470712-B2 Amino-benzazoles as P2Y1 receptor inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-12-30 US disclosed
US-7470712-B2 Amino-benzazoles as P2Y1 receptor inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-12-30 US disclosed
EP-1996180-A1 ANTIBACTERIAL AGENTS Prolysis Limited (GB) 2008-12-03 EP disclosed
US-20080275090-A1 AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS BRISTOL-MYERS SQUIBB COMPANY 2008-11-06 US disclosed
US-20080275090-A1 AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS BRISTOL-MYERS SQUIBB COMPANY 2008-11-06 US disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TDP1 3078/4885L3MBTL1 703/4885SMN1; SMN2 1208/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 TDP1 2148/4885L3MBTL1 377/4885SMN1; SMN2 2959/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TDP1 3078/4885L3MBTL1 703/4885SMN1; SMN2 1208/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 TDP1 3078/4885L3MBTL1 703/4885SMN1; SMN2 1208/4885
US-20080275090-A1 AMINO-BENZAZOLES AS P2Y1 RECEPTOR INHIBITORS WITH PYRIDINE RING AND HETEROCYCLIC COMPONENTS P2RY1, P2RY11, P2RY2 TDP1 1894/4885L3MBTL1 4851/4885SMN1; SMN2 3992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.