Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024055 | 0.79 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL16741679 | 0.76 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3THRB | |
| SCHEMBL16741372 | 0.76 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3THRB | |
| SCHEMBL19814582 | 0.76 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3THRB | |
| SCHEMBL2028828 | 0.76 | THRB (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3THRB | |
| SCHEMBL2713474 | 0.75 | HDAC6 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2713471 | 0.75 | HDAC6 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14842276 | 0.75 | HDAC6 (0.33) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL20550625 | 0.75 | — | — | |
| SCHEMBL29448013 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516434-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011079051-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | WO | disclosed |