Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249204 | 0.95 | CA2 (0.43) | CA2CYP4F2CYP4A11CCR9NFKB1 | |
| SCHEMBL15799967 | 0.87 | TKT (0.42) | CA2CYP4F2CYP4A11CCR9NFKB1 | |
| SCHEMBL25101288 | 0.84 | RAB9A (0.49) | CA2NFKB1MAPTL3MBTL1KDM4E | |
| SCHEMBL11937229 | 0.83 | RAB9A (0.51) | CA2NFKB1MAPTL3MBTL1KDM4E | |
| SCHEMBL7993760 | 0.83 | TKT (0.48) | CA2CYP4F2CYP4A11NFKB1MAPT | |
| SCHEMBL10262595 | 0.82 | NFKB1 (0.51) | CA2NFKB1MAPTL3MBTL1KDM4E | |
| SCHEMBL619744 | 0.80 | CCR9 (0.40) | CA2CCR9ALDH1A1RAB9ANPC1 | |
| SCHEMBL20249198 | 0.79 | HSD17B10 (0.49) | CCR9NFKB1MAPTL3MBTL1KDM4E | |
| SCHEMBL16544500 | 0.78 | SMN1; SMN2 (0.41) | CA2CCR9NFKB1MAPTL3MBTL1 | |
| SCHEMBL20249200 | 0.77 | HRH3 (0.38) | CA2CCR9NFKB1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | CA2 2465/4885CYP4F2 805/4885CYP4A11 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.