Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350709 | 0.97 | LMNA (0.40) | LMNAHTTMEN1KMT2AMAPT | |
| Sulfuric Acid SCHEMBL4604131 | 0.88 | MAPT (0.45) | LMNAHTTMEN1KMT2AMAPT | |
| Sulfuric Acid SCHEMBL5371996 | 0.86 | MAPT (0.44) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL2031262 | 0.86 | MAPT (0.44) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL5462937 | 0.85 | LMNA (0.41) | LMNAHTTMEN1KMT2AMAPT | |
| Sulfuric Acid SCHEMBL4604006 | 0.85 | MAPT (0.43) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL4603649 | 0.82 | LMNA (0.41) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL14811317 | 0.82 | LMNA (0.56) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL28339818 | 0.82 | LMNA (0.37) | LMNAHTTMEN1KMT2AMAPT | |
| Trifluoromethanesulfonic Acid SCHEMBL31169577 | 0.81 | MEN1 (0.40) | LMNAHTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778176-B1 | COMPOSITION FOR COLOURING KERATIN-CONTAINING FIBRES | HENKEL AG & CO KGAA (DE) | 2012-07-25 | — | — | EP | claimed |
| EP-1432388-B1 | AGENT FOR COLOURING FIBRES CONTAINING KERATIN | HENKEL AG & CO KGAA (DE) | 2008-06-18 | — | — | EP | claimed |
| US-7374580-B2 | Dyeing compositions comprising A 1,2-indandione derivative | L'OREAL S.A. (FR) | 2008-05-20 | — | — | US | claimed |
| EP-1502580-B1 | Use in dyeing of aromatic polycyclic vicinal triones with condensed cycles | OREAL (FR) | 2008-01-23 | — | — | EP | claimed |
| EP-1500387-B1 | Use of ninhydrin derivatives for dyeing | OREAL (FR) | 2008-01-09 | — | — | EP | claimed |
| US-7300472-B2 | Agents for coloring fibers containing keratin | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-11-27 | — | — | US | claimed |
| US-7192455-B2 | Process for dyeing keratin fibers with at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2007-03-20 | — | — | US | claimed |
| US-7182790-B2 | Use of at least one ninhydrin derivative for dyeing | L'OREAL S.A. (FR) | 2007-02-27 | — | — | US | claimed |
| US-7182791-B2 | Composition and method of dyeing keratin fibers comprising at least one heteroalkyl group comprising at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2007-02-27 | — | — | US | claimed |
| EP-1200049-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2007-02-21 | — | — | EP | claimed |
| EP-1432388-A1 | AGENT FOR COLOURING FIBRES CONTAINING KERATIN | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | claimed |
| EP-1139990-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2004-05-06 | — | — | EP | claimed |
| EP-1362579-A1 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-11-19 | — | — | EP | claimed |
| WO-2003030845-A1 | AGENT FOR THE COLORATION OF KERATIN-CONTAINING FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | claimed |
| WO-2003030847-A1 | AGENT FOR COLOURING FIBRES CONTAINING KERATIN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | claimed |
| EP-1300132-A2 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | claimed |
| EP-1300135-A1 | Agent for dyeing keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-04-09 | — | — | EP | claimed |
| EP-1139988-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2002-09-25 | — | — | EP | claimed |
| EP-1199065-A2 | Hair dye | Henkel Kommanditgesellschaft auf Aktien (DE) | 2002-04-24 | — | — | EP | claimed |
| WO-2001089587-A2 | AGENTS FOR DYEING FIBRES CONTAINING KERATIN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-11-29 | — | — | WO | claimed |