Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20240839 | 1.00 | MAPT (0.47) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL27705676 | 0.87 | RAB9A (0.50) | MAPTGAAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL10004632 | 0.84 | MAPT (0.51) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL10004634 | 0.84 | MAPT (0.51) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL10004639 | 0.84 | MAPT (0.51) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL3199741 | 0.84 | ALDH1A1 (0.50) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL3199745 | 0.84 | ALDH1A1 (0.50) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8996022 | 0.84 | ALDH1A1 (0.51) | MAPTGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8996062 | 0.84 | SMN1; SMN2 (0.54) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL19732872 | 0.82 | SOAT2 (0.56) | ALDH1A1HTTNPSR1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | BEIGENE, LTD. (KY) | 2023-08-15 | — | — | US | disclosed |
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | BEIGENE, LTD. (KY) | 2023-08-15 | — | — | US | disclosed |
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | BEIGENE, LTD. (KY) | 2023-08-15 | — | — | US | disclosed |
| US-20220098202-A1 | IMIDAZO[1,5-a]PYRAZINE DERIVATIVES AS PI3K DELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2022-03-31 | — | — | US | disclosed |
| US-20220098202-A1 | IMIDAZO[1,5-a]PYRAZINE DERIVATIVES AS PI3K DELTA INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2022-03-31 | — | — | US | disclosed |
| US-11136323-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | BEIGENE, LTD. (KY) | 2021-10-05 | — | — | US | disclosed |
| WO-2018103688-A1 | IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | BEIGENE, LTD. (KY) | 2018-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098202-A1 | IMIDAZO[1,5-a]PYRAZINE DERIVATIVES AS PI3K DELTA INHIBITORS | PIK3CD, PIK3R5, PIK3CA | MAPT 3882/4885GAA 1032/4885ALDH1A1 1902/4885 |
| US-11136323-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | PIK3CD, PIK3R5, PIK3CA | MAPT 4070/4885GAA 801/4885ALDH1A1 1964/4885 |
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | PIK3CD, PIK3R5, PIK3CA | MAPT 3924/4885GAA 859/4885ALDH1A1 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.