Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 11/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20260395 | 0.94 | P2RX7 (0.39) | TTKP2RX7PIK3CAMAPK8MAPK10 | |
| SCHEMBL18278673 | 0.89 | MAPK8 (0.36) | TTKP2RX7PIK3CAMAPK8MAPK10 | |
| SCHEMBL18277739 | 0.89 | MAPK10 (0.36) | TTKP2RX7PIK3CAMAPK8MAPK10 | |
| SCHEMBL20260363 | 0.84 | TTK (0.44) | TTKP2RX7PIK3CAACVR1 | |
| SCHEMBL20260939 | 0.84 | P2RX7 (0.39) | TTKP2RX7MAPK8MAPK10MAPK9 | |
| SCHEMBL20260924 | 0.84 | MAPK8 (0.35) | TTKMAPK8MAPK10MAPK9ACVR1 | |
| SCHEMBL20260873 | 0.83 | MAPT (0.42) | MAPK8MAPK10MAPK9 | |
| SCHEMBL20242649 | 0.83 | MAPK14 (0.38) | TTKMAPK8MAPK10MAPK9ACVR1 | |
| SCHEMBL18278851 | 0.83 | MAPK8 (0.34) | TTKMAPK8MAPK10MAPK9ACVR1 | |
| SCHEMBL18278868 | 0.83 | MAPK8 (0.34) | TTKMAPK8MAPK10MAPK9ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |